In cesium, there are a pair of energy states, so to make it easier, let’s refer to these as state A and state B, respectively.įirst, atoms are heated and bundled into a beam. The first thing to understand is atoms can be in different energy states, called hyperfine levels or hyperfine structure in scientific terms. But what you may not know is while they are identical in principle and function - like traditional clocks - there are many types. This is why atomic clocks are one of the most accurate devices we have to tell time. Yet, atomic clocks are more precise because natural atomic oscillations happen at a higher frequency and as a result they are more stable. ![]() Well, the natural way that atoms oscillate works similar to a pendulum in an atomic clock. You know what a pendulum in a grandfather clock is, right? It is a harmonic oscillator that uses gravity to swing back and forth, and this motion helps the clock keep time. Precise measurements – like those from atomic clocks – also help operate satellite navigation systems like GPS, Galileo, and GLONASS. And since UTC is the standard we use to keep all the clocks in the world synced, atomic clocks are pretty important. Please note, this only applies to a cesium atom currently at rest at 0 Kelvin.Īn estimated 400 clocks worldwide contribute to International Atomic Time (TAI), a time standard we use to maintain Coordinated Universal Time (UTC). “The second is the duration of 9,192,631,770 periods of the radiation corresponding to the transition between the two hyperfine levels of the ground state of the caesium-133 atom.” We can also refer to the true definition, which is much more complex. ![]() An atomic clock is a device that measures time using the microwave signal emitted by atoms – or the electrons in atoms – when they change energy levels.ĭid you know atomic clocks only have an error of 1 second in a span of about one-hundred million years? This makes them one of the most accurate devices in human history, at least when it comes to keeping time.Ītomic clocks measure the actual length of a second, which is the base unit we use to calculate time.Īccording to the International System of Units (SI), the time unit "second" is calculated by the time an atom in a defined state - comprised of the element caesium-133 - takes to oscillate 9,192,631,770 times.
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One of the most exciting new features in this update is the ability to set the visibility of new collections and galleries from within Photo Mechanic. Set permissions from within Photo Mechanic This feature removes the need to flip back and forth between Photo Mechanic and your web browser to set up new collections/galleries thereby lessening the number of steps to publish. You can now create new PhotoShelter collections and galleries from within Photo Mechanic. This makes uploading new images to existing galleries (even ones that are nested several levels deep) both fast and predictable. The new uploader allows you to see the exact collection and gallery structure of your PhotoShelter account in a familiar left-to-right column layout. Save a copy of uploaded photos to a local folderīrowse your PhotoShelter collection/gallery structure.Switch between multiple PhotoShelter accounts, including Multi-User.Streamlined interface for dramatically improved ease of use.Fewer steps to select, edit, upload, and publish images.Opt to skip or rename files that already exist on PhotoShelter. ![]() Make images publicly searchable during upload.Set visibility permissions of new collections/galleries without leaving Photo Mechanic.Switch between the “listed” and “unlisted” sections of PhotoShelter and create new galleries/collections in either section.Create new PhotoShelter collections/galleries inside Photo Mechanic.Browse your PhotoShelter collection/gallery structure from within Photo Mechanic.Upload directly to PhotoShelter without leaving Photo Mechanic.(There are special deals on both at the bottom of this post). If you have either PhotoShelter or Photo Mechanic, now’s the time to try these two power-tools together to improve your workflow from shoot to publish. This update makes the process of uploading to PhotoShelter from Photo Mechanic faster, more stable, and significantly more useful. It allows you to ingest, select, edit, and distribute photos faster and more efficiently than any other program we’ve found. And, though you’ve been able to upload to PhotoShelter directly from Photo Mechanic for years now, the latest uploader contains more than a few new features and improvements worth getting excited about. For those of you not familiar with Photo Mechanic, it’s an incredibly fast and full-featured desktop image browser. We’re very excited to announce the launch of a brand new PhotoShelter uploader tool inside Photo Mechanic Version 5 (Build 15002). ![]() isInvalidDate: (function) A function that is passed each date in the twoĬalendars before they are displayed, and may return true or false to indicate whether.When disabled, the two calendars can be individually advanced and display any month/year. January and February), and both will be advanced when clicking the left or right arrows above the calendars. linkedCalendars: (true/false) When enabled, the two calendars displayed will always be for two sequential months (i.e.autoApply: (true/false) Hide the apply and cancel buttons, and automatically apply a new date range as soon as two dates are clicked.The start and end dates provided to your callback will be the same single date chosen. singleDatePicker: (true/false) Show only a single calendar to choose one date, instead of a range picker with two calendars.locale: (object) Allows you to provide localized strings for buttons and labels, customize the date format, and change the first day of week for the calendars.Ĭheck off locale in the configuration generator to see how.cancelButtonClasses: (string) CSS class names that will be added only to the cancel button.applyButtonClasses: (string) CSS class names that will be added only to the apply button.buttonClasses: (string) CSS class names that will be added to both the apply and cancel buttons.drops: ('down'/'up'/'auto') Whether the picker appears below (default) or above the HTML element it's attached to.opens: ('left'/'right'/'center') Whether the picker appears aligned to the left, to the right, or centered under the HTML element it's attached to.When this option is set to true, the calendars for choosing a custom date range are always shown instead. alwaysShowCalendars: (true/false) Normally, if you use the ranges option to specify pre-defined date ranges, calendars for choosing a custom date range are not shown until the user clicks "Custom Range".Clicking it will display the calendars to select a new range. This option will be highlighted whenever the current date range selection does not match one of the predefined ranges. The end of the list of predefined ranges, when the ranges option is used. showCustomRangeLabel: (true/false) Displays "Custom Range" at.Click ranges in the configuration generator for examples. Each key is the label for the range, and its value an array with two dates representing the bounds of the range. ![]() ranges: (object) Set predefined date ranges the user can select from.timePickerSeconds: (true/false) Show seconds in the timePicker.timePicker24Hour: (true/false) Use 24-hour instead of 12-hour times, removing the AM/PM selection.30 to allow only selection of times ending in 0 or 30). timePickerIncrement: (number) Increment of the minutes selection list for times (i.e.timePicker: (true/false) Adds select boxes to choose times in addition to dates.showISOWeekNumbers: (true/false) Show ISO week numbers at the start of each week on the calendars.showWeekNumbers: (true/false) Show localized week numbers at the start of each week on the calendars.maxYear: (number) The maximum year shown in the dropdowns when showDropdowns is set to true.minYear: (number) The minimum year shown in the dropdowns when showDropdowns is set to true.showDropdowns: (true/false) Show year and month select boxes above calendars to jump to a specific month and year.You can provide any object the moment library would let you add to a date. Check off maxSpan in the configuration generator for an example of how to use this. maxSpan: (object) The maximum span between the selected start and end dates.maxDate: (Date or string) The latest date a user may select.minDate: (Date or string) The earliest date a user may select.endDate: (Date or string) The end date of the initially selected date range. ![]() If you provide a string, it must match the date format string set in your locale setting.
![]() : So, boredom, then? In case you haven't noticed, you don't have a monopoly on tragedy here. Of course, Matkina is attracted to Aligern's mysterious past. Remember him? We beat him in a drinking contest, and then we made him get eaten by the Trolley Door? Orth Faung can be found dicking around the place we sent Artaglio to his death. : I let her down and we had an awful relationship. : So, uh, what's with you and my girl Callistege? : So, you have a friend at the Order? Who? : A memento left by the monsters who killed my family. Look at us! There are nanomachines everywhere, but we're still stuck in the Middle Ages! I only have one friend in the Order of Truth, he's a bro who helped me with it. But they said I was obsessed, just because i wanted to find the Changing God who killed my whole family. TheGreatEvilKing summary posted: : Hey, tell me about yourself. This exhausts the personal history questions and I cut it there. Oh well! We don't have the option to tell him we broke them up. ![]() This is kind of interesting as Aligern admits fault here, while Callistege is still so pissed she makes catty comments about him every so often. : Did you and Callistege have a.relationship? : How did you come to travel with Callistege? : Who's your friend at the Order of Truth? : Can you tell me about your tattoos? They look almost alive. We exchange these little pleasantries every time we meet." They think I'm carked, and I think they're frauds. The Aeon Priests are Numenera's version of scientists, studying the artifacts of the ancient worlds so the world can maintain its Dungeons and Dragons style of living. The Changing God showed up with a magic picture frame that killed his whole family and left him with the snake tattoos. : You said "things happened" that made you leave your village. So, uh.we missed a bunch of stuff in part two with Aligern. Callistege is missing a lot of spells off her nano list, so who knows? I'm not sure if you can give him Flash and Maelstrom and have him go to town nuking things. He has the nano class, but he's explicitly specced as a D&D cleric. Notice the mace and the healing spell? Yeah, Aligern is a D&D cleric. We are also dragging around a terminally underleveled Matkina because Rhin left us after our misadventures in The Slum of Sexual Harassment. He has no edge and his skills are much weaker than the rest of the team's. Or something.įUCK! Aligern does come with the game's healing spell, but he can't really heal that much because he's still.Tier 1. As the thread commented, this means our team is really shit in fights.įortunately Aligern has our back because we helped Daddy-bot that one time. Unfortunately, this means we need to boot Callistege for a little while. Now, we're gonna hang out with Aligern and see what his deal is. Last time, on Tides of Numenera, we caused a murder robot to question his morality then murdered him for Silver Tide points. Part 41: It's Just A Prank, Bro! The Changing God Pranked You, Bro! It's Just A Prank, Bro! The Changing God Pranked You, Bro! The first defining moment was the invention of the prototype Ur-Leica (a portable unit designed to test motion picture film speed) by Leitz engineer Oskar Barnack in 1913. Ernst Leitz GmbH, which was founded originally as an optical company, was formed in 1849 by Ernst Leitz. ![]() The camera is considered to be Leica’s masterpiece by many, but how and why did this arise?īefore we can understand the Leica M3, we need to understand Leica, the company, and the mystique. In this article, we will explore why the Leica M3 remains one of Leica’s most celebrated and in-demand models over half a century after it was first launched. In today’s world of ever-increasing resolution - commercial cameras now boast over 150 megapixels - analog will always be a disadvantage given the physical limits of 35mm or 120mm (6×6) film, but the darkroom practice and the skill required to shoot a completely mechanical camera still has a particular allure on budding young photographers as well as those more advanced in age who had experienced analog photography before. ![]() While many M cameras have followed in its footsteps, the Leica M3 is still one of the most popular models alike among both collectors and photographers.Īnalog or film photography is seeing a resurgence in interest and uptake. ![]() Introduced in 1954 and produced until 1966, the Leica M3 was the first model in the famous Leica M rangefinder line that continues to see new cameras produced in the digital age. Of these, 699 were collected in Africa (Burkina Faso, Cameroon, Guinea, Kenya, Malawi, Mali, and Tanzania), 69 in South America (Brazil, Colombia, French Guiana, and Peru), 59 in Oceania (Papua New Guinea), and 183 in Asia (Cambodia, Myanmar, and Thailand). To evaluate the vaccine escape potential of antigens used in vaccines currently in development or clinical testing, we surveyed the genetic diversity, measured population differentiation, and performed in silico prediction and analysis of T-cell epitopes of ten such Plasmodium falciparum pre-erythrocytic-stage antigens using whole-genome sequence data from 1010 field isolates. Thus, this study provides relevant knowledge of genetic and technical deliberations that can improve the state-of-the-art methods for predicting individual malaria risk.įailure to account for genetic diversity of antigens during vaccine design may lead to vaccine escape. Moreover, the deep learning model obtained almost similar MAE scores to the machine learning models, indicating an alternative approach. In addition, incorporating the mutation location significantly improved the machine learning models in predicting the individual malaria risk a Mean Absolute Error (MAE) score of 8.00E−06. The findings of this study demonstrated that the proposed GA could overcome the curse of dimensionality and improve resource efficiency compared to commonly used methods. The analysis is performed on the Malaria Genomic Epidemiology Network (MalariaGEN) dataset comprising 20,817 individuals from 11 populations. Besides that, a deep learning model is also proposed to predict individual malaria risk as an alternative approach. Therefore, this study proposes a machine learning model that incorporates mutation location as well as a Genetic Algorithm (GA) to optimize hyperparameters. Nevertheless, it becomes computationally expensive for hyperparameter optimization on large-scale datasets. Thus, the present study improves the current state-of-the-art genetic risk score by incorporating SNPs mutation location on large-scale genetic variation data obtained from GWAS. Furthermore, many Genome-Wide Associations Studies (GWAS) have associated specific genetic markers, i.e., single nucleotide polymorphisms (SNPs), with malaria. However, a machine learning model based on genetic variation data is still required to fully explore individual malaria risk. ![]() In recent malaria research, the complexity of the disease has been explored using machine learning models via blood smear images, environmental, and even RNA-Seq data. Furthermore, based on wGRS + GF, all models performed significantly better than wGRS alone, in which LightGBM obtained the best performance (0.0033 MAE score). ![]() The analysis and comparison of the three machine learning models demonstrated that LightGBM achieves the highest model performance with a Mean Absolute Error (MAE) score of 0.0373. This is an important result as prior studies have proven that rs334 is a major genetic risk factor for malaria. Our proposed approach identified SNP rs334 as the most contributing feature with an importance score of 6.224 compared to the baseline, with an importance score of 1.1314. Finally, Light Gradient Boosting Machine (LightGBM), eXtreme Gradient Boosting (XGBoost), and Ridge regression algorithms are utilized to establish the machine learning models for malaria risk prediction. Moreover, to compare the performance of the wGRS-only model, we calculated and evaluated the combination of wGRS with genotype frequency (wGRS + GF). Next, we calculated the wGRS of the selected feature set, which is used as the model's target variables. Therefore, we reduced the feature set by employing the Logistic Regression and Recursive Feature Elimination (LR-RFE) method to select SNPs that improve the efficacy of our model. However, it can become computationally expensive for a machine learning model to learn from many SNPs. We proposed an SNP-based feature extraction algorithm that incorporates the susceptibility information of an individual to malaria to generate the feature set. ![]() More specifically, this study aims to quantify an individual's susceptibility to the development of malaria by using risk scores obtained from the cumulative effects of SNPs, known as weighted genetic risk scores (wGRS). ![]() However, to the best of our knowledge, no study analyses the contribution of Single Nucleotide Polymorphisms (SNPs) to malaria using a machine learning model. 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New!!: Valentina Vargas and The Shipwrecked The Shipwrecked (Los náufragos) is a 1994 Chilean drama film directed by Miguel Littín. New!!: Valentina Vargas and The Name of the Rose (film) ![]() The Name of the Rose is a 1986 Italian-French-German drama mystery film directed by Jean-Jacques Annaud, based on the book of the same name by Umberto Eco. New!!: Valentina Vargas and The Big Blue ![]() The Big Blue (released in some countries under the French title Le Grand Bleu) is a 1988 English-language film in the French Cinéma du look visual style, made by French director Luc Besson. New!!: Valentina Vargas and Street of No Return Street of No Return is a 1989 crime film directed by Samuel Fuller and starring Keith Carradine and Valentina Vargas. New!!: Valentina Vargas and Night Across the Street Night Across the Street (La noche de enfrente) is a 2012 Chilean drama film directed by Raúl Ruiz. New!!: Valentina Vargas and List of horror films of 1996 New!!: Valentina Vargas and List of Hellraiser cast members List of actors appearing in Hellraiser and its sequels. See more » List of Hellraiser cast members.New!!: Valentina Vargas and List of German films of the 1990s ![]() This is a list of the most notable films produced in Cinema of Germany in the 1990s. See more » List of German films of the 1990s.New!!: Valentina Vargas and List of crime films of the 1980s See more » List of crime films of the 1980sĪ list of crime films released in the 1980s.New!!: Valentina Vargas and List of Chilean actors and actresses This is a non-exhaustive list of famous Chilean actors and actresses of film, television, theatre, radio, and others. See more » List of Chilean actors and actresses.New!!: Valentina Vargas and List of Chile-related topics The following is an outline of topics related to the Republic of Chile. New!!: Valentina Vargas and Julien Magnat Julien Magnat is a film and television screenwriter and director. New!!: Valentina Vargas and Index of Chile-related articles The following is an alphabetical list of articles related to the Republic of Chile. See more » Index of Chile-related articles.New!!: Valentina Vargas and Hellraiser: Bloodline Hellraiser: Bloodline (also known as Hellraiser IV: Bloodline) is a 1996 American science-fiction horror film and the fourth installment in the ''Hellraiser'' series, which serves as both a prequel and a sequel. New!!: Valentina Vargas and Faces in the Crowd (film) New!!: Valentina Vargas and Deseo (album) įaces in the Crowd is a 2011 British-Canadian-American crime drama horror thriller film written and directed by Julien Magnat, starring Milla Jovovich, Julian McMahon, David Atrakchi, Michael Shanks, Sandrine Holt, and Sarah Wayne Callies. New!!: Valentina Vargas and Cinema of Chile ĭeseo (meaning desire or wish) is the sixth solo album by Yes lead singer Jon Anderson, released in 1994. New!!: Valentina Vargas and Bloody Mallory Ĭhilean cinema refers to all films produced in Chile or made by Chileans. New!!: Valentina Vargas and All Inclusive (2008 film) īloody Mallory is a 2002 film directed by Julien Magnat at his directorial debut, and written by Magnat and Stéphane Kazandjian. All Inclusive (2008 film)Īll Inclusive (Spanish: Todo incluido) is a 2008 Chilean-Mexican movie. Ģ3 relations: All Inclusive (2008 film), Bloody Mallory, Cinema of Chile, Deseo (album), Faces in the Crowd (film), Hellraiser: Bloodline, Index of Chile-related articles, Julien Magnat, List of Chile-related topics, List of Chilean actors and actresses, List of crime films of the 1980s, List of German films of the 1990s, List of Hellraiser cast members, List of horror films of 1996, Night Across the Street, Street of No Return, The Big Blue, The Name of the Rose (film), The Shipwrecked, The Tigress (1992 film), Twin Sitters, Vargas (surname), 1986 in film. 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